There are many causes of glutathione levels decreasing in the body, including environmental toxins, poor diet, stress, aging, infections, chemotherapy and pollution
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The discovery of its biological activity came from an unexpected observation: serum from young donors (age 20-25) could stimulate aged liver tissue to synthesize proteins at a rate characteristic of younger tissue, while serum from older donors (age 60-80) could not
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Contraindications and cautions include asthma (glutathione may trigger bronchospasm in sensitive individuals), platinum-based chemotherapy (glutathione may reduce drug efficacy), and certain genetic variations affecting cysteine and sulfur metabolism